The content of chromium, manganese, copper and zinc in plasma and red blood cells in mothers and their newborns with a threatened pregnancy in the anamnesis

Objective. To study the changes in concentration of transition metals — chrome, manganese, copper and zinc — in peripheral blood serum and erythrocytes of women in labor and their newborns with the history of threatened pregnancy. To study the cell-membrane permeability indices.Characteristics of children and research methods. The authors selected 97 couples of the full-term newborns and their mothers. The test group (Group 1) included 57 couples with threatened pregnancy. The control group (Group 2) included 40 conditionally healthy couples of mother and child. The concentrations of chemical elements were determined in plasma and red blood cells by inductively coupled plasma mass spectrometry (ICP-MS). There were two stages of statistical processing. Initially, there were determined the parameters with a reliable change in the concentration of elements in women with threatened pregnancy. Then, the scientists calculated the relation values between all parameters for each element.Results. We observed the increase in concentration of chrome, manganese and zinc in the women in labor with the threatened pregnancy as compared to healthy women in labor. At the same time, zinc and chrome take the most active part in compensatory mechanisms of preservation of pregnancy. We observed the increase in intracellular manganese against the background of its reduction in plasma in the newborns born from mothers with threatened pregnancy. At the same time, the authors found the difference in the functioning of the erythrocyte membrane in relation to copper in mothers and newborns