Trypanosoma cruzi is a flagellate protozoan pathogen that causes Chagas disease. Currently there is no preventive treatment and the efficiency of the two drugs available is limited to the acute phase. Therefore, there is an unmet need for innovative tools to block transmission in endemic areas. In this study, we engineered a novel recombinant molecule able to adhere to the T. cruzi surface, termed scFv-10D8, that consists of a single-chain variable fragment (scFv) derived from mAb-10D8 that targets gp35/50. The synthetic gene encoding scFv-10D8 was cloned and fused to a 6×His tag and expressed in a prokaryotic expression system. Total periplasmic or 6xHis tag affinity-purified fractions of scFv-10D8 retained the capacity to bind to gp35/50,...
The identification of new targets for vaccine and drug development for the treatment of Chagas' dise...
Trypanosoma cruzi, the etiologic agent of Chagas disease is a protozoan very important in South Amer...
Chagas disease is the clinical manifestation of the infection produced by the parasite Trypanosoma c...
International audienceTrypanosoma cruzi is a flagellate protozoan pathogen that causes Chagas diseas...
The protozoan Trypanosoma cruzi is the etiological agent of Chagas' disease, a major chronic infecti...
The protozoan Trypanosoma cruzi is the etiological agent of Chagas´ disease, a major chronic infecti...
Chagas disease is a neglected tropical disease caused by the parasite Trypanosoma cruzi. Despite the...
Trypanosoma cruzi is a single-celled parasite found in the Americas, from the southern United States...
Infection with Trypanosoma cruzi causes Chagas disease, a major public health problem throughout Lat...
Numerous immunization approaches against Trypanosoma cruzi infection have been tested for decades, r...
Trypanosoma cruzi is the protozoan parasite that causes Chagas disease, which is considered by the W...
<div><p>Background</p><p>Chagas disease, also known as American Trypanosomiasis, is a chronic parasi...
Infection with Trypanosoma cruzi causes Chagas disease, a major public health problem throughout Lat...
The parasite Trypanosoma cruzi is the causative agent of Chagas disease, a potentially life-threaten...
Experimenal vaccines against T. cruzi infection have only been assayed in murine laboratory models a...
The identification of new targets for vaccine and drug development for the treatment of Chagas' dise...
Trypanosoma cruzi, the etiologic agent of Chagas disease is a protozoan very important in South Amer...
Chagas disease is the clinical manifestation of the infection produced by the parasite Trypanosoma c...
International audienceTrypanosoma cruzi is a flagellate protozoan pathogen that causes Chagas diseas...
The protozoan Trypanosoma cruzi is the etiological agent of Chagas' disease, a major chronic infecti...
The protozoan Trypanosoma cruzi is the etiological agent of Chagas´ disease, a major chronic infecti...
Chagas disease is a neglected tropical disease caused by the parasite Trypanosoma cruzi. Despite the...
Trypanosoma cruzi is a single-celled parasite found in the Americas, from the southern United States...
Infection with Trypanosoma cruzi causes Chagas disease, a major public health problem throughout Lat...
Numerous immunization approaches against Trypanosoma cruzi infection have been tested for decades, r...
Trypanosoma cruzi is the protozoan parasite that causes Chagas disease, which is considered by the W...
<div><p>Background</p><p>Chagas disease, also known as American Trypanosomiasis, is a chronic parasi...
Infection with Trypanosoma cruzi causes Chagas disease, a major public health problem throughout Lat...
The parasite Trypanosoma cruzi is the causative agent of Chagas disease, a potentially life-threaten...
Experimenal vaccines against T. cruzi infection have only been assayed in murine laboratory models a...
The identification of new targets for vaccine and drug development for the treatment of Chagas' dise...
Trypanosoma cruzi, the etiologic agent of Chagas disease is a protozoan very important in South Amer...
Chagas disease is the clinical manifestation of the infection produced by the parasite Trypanosoma c...