Phage therapy offers a potential alternate strategy for the treatment of peri-prosthetic joint infection (PJI), particularly where limited effective antibiotics are available. We undertook preclinical trials to investigate the therapeutic efficacy of a phage cocktail, alone and in combination with vancomycin, to reduce bacterial numbers within the infected joint using a clinically-relevant model of Staphylococcus aureus-induced PJI. Infected animals were randomised to 4 treatment groups, with treatment commencing 21-days post-surgery: bacteriophage alone, vancomycin alone, bacteriophage and vancomycin, and sham. At day 28 post-surgery, animals were euthanised for microbiological and immunological assessment of implanted joints. Treatment wi...
International audienceStaphylococcus aureus ( S. aureus ) is a common and virulent human pathogen ca...
Bacteriophages are viruses that specifically target bacteria. They are considered to have a high pot...
<div><p><i>Staphylococcus</i> comprises up to two-thirds of all pathogens in orthopaedic implant inf...
Phage therapy offers a potential alternate strategy for the treatment of peri-prosthetic joint infec...
The increase in the incidence rate of multidrug resistant strains of bacteria has prompted scientist...
Bacterial resistance to antibiotics has catalysed interest in alternative antimicrobial strategies. ...
Bone and joint infections are difficult to treat, and increasing antibiotic resistance has only made...
Implant-associated infections are the most costly problem in modern orthopedics due to the continued...
Background: Despite significant advancements in surgical protocols and biomaterials for orthopedics,...
Staphylococcus aureus is responsible for difficult-to-treat bone and joint infections (BJIs). This i...
Prosthetic joint infections are a devastating complication of joint replacement surgery. Consequentl...
Chronic prosthetic joint infections are difficult to treat without conducting revision surgery becau...
Phage-derived therapies comprise phage therapy and the use of phage-derived proteins as anti-bacteri...
Staphylococcus aureus causes the majority of implant-related infections. These infections present as...
The placement of indwelling medical devices, such as pacemakers, coronary stents, orthopedic articul...
International audienceStaphylococcus aureus ( S. aureus ) is a common and virulent human pathogen ca...
Bacteriophages are viruses that specifically target bacteria. They are considered to have a high pot...
<div><p><i>Staphylococcus</i> comprises up to two-thirds of all pathogens in orthopaedic implant inf...
Phage therapy offers a potential alternate strategy for the treatment of peri-prosthetic joint infec...
The increase in the incidence rate of multidrug resistant strains of bacteria has prompted scientist...
Bacterial resistance to antibiotics has catalysed interest in alternative antimicrobial strategies. ...
Bone and joint infections are difficult to treat, and increasing antibiotic resistance has only made...
Implant-associated infections are the most costly problem in modern orthopedics due to the continued...
Background: Despite significant advancements in surgical protocols and biomaterials for orthopedics,...
Staphylococcus aureus is responsible for difficult-to-treat bone and joint infections (BJIs). This i...
Prosthetic joint infections are a devastating complication of joint replacement surgery. Consequentl...
Chronic prosthetic joint infections are difficult to treat without conducting revision surgery becau...
Phage-derived therapies comprise phage therapy and the use of phage-derived proteins as anti-bacteri...
Staphylococcus aureus causes the majority of implant-related infections. These infections present as...
The placement of indwelling medical devices, such as pacemakers, coronary stents, orthopedic articul...
International audienceStaphylococcus aureus ( S. aureus ) is a common and virulent human pathogen ca...
Bacteriophages are viruses that specifically target bacteria. They are considered to have a high pot...
<div><p><i>Staphylococcus</i> comprises up to two-thirds of all pathogens in orthopaedic implant inf...