Upon myocardial damage, the release of cardiac proteins induces a strong antibody-mediated immune response, which can lead to adverse cardiac remodeling and eventually heart failure (HF). Stem cell therapy using mesenchymal stromal cells (MSCs) or cardiomyocyte progenitor cells (CPCs) previously showed beneficial effects on cardiac function despite low engraftment in the heart. Paracrine mediators are likely of great importance, where, for example, MSC-derived extracellular vesicles (EVs) also show immunosuppressive properties in vitro. However, the limited capacity of MSCs to differentiate into cardiac cells and the sufficient scaling of MSC-derived EVs remain a challenge to clinical translation. Therefore, we investigated the immunosuppre...
Purpose of review For heart failure patients, the urgent need for heart transplantation exceeds the ...
Despite seminal advances in its management, the burden of cardiomyopathy remains substantial, provid...
Based on data from the World Healthcare Organisation, cardiovascular diseases are the primary cause ...
Upon myocardial damage, the release of cardiac proteins induces a strong antibody-mediated immune re...
Adverse remodeling after myocardial infarction (MI) is strongly influenced by T cells. Stem cell the...
International audienceThe cardioprotective effects of human induced pluripotent stem cell-derived ca...
Abstract Background Optimal cell type as cell-based therapies for heart failure (HF) remains unclear...
Conference Theme: An Unveiling of Stem Cell InnovationPluripotent stem cell-derived cardiac progenit...
[[abstract]]Ischemic heart damage usually triggers cardiomyopathological remodeling and fibrosis, th...
Background—Cardiac cell therapy for older patients who experience a myocardial infarction may requir...
The pandemic of cardiovascular disease is continuously expanding as the result of changing life styl...
The pandemic of cardiovascular disease is continuously expanding as the result of changing life styl...
Abstract While existing remedies failed to fully address the consequences of heart failure, stem cel...
Cardiovascular disease usually triggers coronary heart disease, stroke, and ischemic diseases, thus ...
Background: The STRO-3 antigen has previously been shown to identify a subset of adult human bone ma...
Purpose of review For heart failure patients, the urgent need for heart transplantation exceeds the ...
Despite seminal advances in its management, the burden of cardiomyopathy remains substantial, provid...
Based on data from the World Healthcare Organisation, cardiovascular diseases are the primary cause ...
Upon myocardial damage, the release of cardiac proteins induces a strong antibody-mediated immune re...
Adverse remodeling after myocardial infarction (MI) is strongly influenced by T cells. Stem cell the...
International audienceThe cardioprotective effects of human induced pluripotent stem cell-derived ca...
Abstract Background Optimal cell type as cell-based therapies for heart failure (HF) remains unclear...
Conference Theme: An Unveiling of Stem Cell InnovationPluripotent stem cell-derived cardiac progenit...
[[abstract]]Ischemic heart damage usually triggers cardiomyopathological remodeling and fibrosis, th...
Background—Cardiac cell therapy for older patients who experience a myocardial infarction may requir...
The pandemic of cardiovascular disease is continuously expanding as the result of changing life styl...
The pandemic of cardiovascular disease is continuously expanding as the result of changing life styl...
Abstract While existing remedies failed to fully address the consequences of heart failure, stem cel...
Cardiovascular disease usually triggers coronary heart disease, stroke, and ischemic diseases, thus ...
Background: The STRO-3 antigen has previously been shown to identify a subset of adult human bone ma...
Purpose of review For heart failure patients, the urgent need for heart transplantation exceeds the ...
Despite seminal advances in its management, the burden of cardiomyopathy remains substantial, provid...
Based on data from the World Healthcare Organisation, cardiovascular diseases are the primary cause ...