Autoantibodies as diagnostic markers and potential drivers of inflammation in ulcerative colitis.
- Henrika Jodeleit
- Lisa Milchram
- Regina Soldo
- Gabriel Beikircher
- Silvia Schönthaler
- Omar Al-Amodi
- Eckhard Wolf
- Florian Beigel
- Andreas Weinhäusel
- Matthias Siebeck
- Roswitha Gropp
DOIAbstract
To date, no comprehensive analysis of autoantibodies in sera of patients with ulcerative colitis has been conducted. To analyze the spectrum of autoantibodies and to elucidate their role serum-IgG from UC patients (n = 49) and non-UC donors (n = 23) were screened by using a human protein microarray. Screening yielded a remarkable number of 697 differentially-reactive at the nominal 0·01 significance level (FDR<0·1) of the univariate test between the UC and the non-UC group. CD99 emerged as a biomarker to discriminate between both groups (p = 1e-04, AUC = 0·8). In addition, cytokines, chemokines and growth factors were analyzed by Olink's Proseek® Multiplex Inflammation-I 96×96 immuno-qPCR assay and 31 genes were significant at the nominal 0...
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