BACKGROUND:The plenteous resistance to and undesirable consequences of the existing antipiroplasmic therapies have emphasized the urgent need for new chemotherapeutics and drug targets for both prophylaxis and chemotherapy. Hydroxyurea (HYD) is an antineoplastic agent with antitrypanosomal activity. Eflornithine (α-difluoro-methyl ornithine, DFMO) is the best choice therapy for the treatment of late-stage Gambian human African trypanosomiasis. METHODS:In this study, the inhibitory and combination efficacy of HYD and DFMO with existing babesicidal drugs (diminazene aceturate (DA), atovaquone (ATV), and clofazimine (CLF)) deoxyribonucleotide in vitro against the multiplication of Babesia and Theileria. As well as, their chemotherapeutic effec...
Trypanosoma brucei are unicellular parasites endemic to Sub-Saharan Africa that cause fatal disease ...
BackgroundSchistosomiasis is highly prevalent in Africa. Praziquantel is effective against adult sch...
<div><p>Novel drugs to treat human African trypanosomiasis (HAT) are still urgently needed despite t...
BackgroundChemotherapy is a principle tool for the control and prevention of piroplasmosis. The sear...
The problems of parasite resistance, as well as the toxic residues to most of the commercially avail...
BackgroundChemotherapy is a principle tool for the control and prevention of piroplasmosis. The sear...
Babesiosis is an emerging tick-borne disease caused by apicomplexan parasites of the genus Babesia. ...
Background:Treatment is the principle way to control and eliminate piroplasmosis. The search for new...
Babesiosis is a tick-transmitted zoonosis caused by apicomplexan parasites of the genus Babesia. Tre...
BACKGROUND: Tafenoquine (TQ) was recently approved by the US Food and Drug Administration for prophy...
Babesia bovis, Babesia bigemina and Theileria equi are worldwide tick-borne hemoprotozoan that cause...
Heat shock protein 90 (Hsp90) is a chaperone protein that stabilizes cells during stress or non-stre...
Piroplasmosis treatment has been based on the use of imidocarb dipropionate or diminazene aceturate ...
Mohamed Abdo Rizk,1,2 Mahmoud AbouLaila,3 Shimaa Abd El-Salam El-Sayed,1,4 Azirwan Guswanto,1,5 Naoa...
The metacestode stage of the fox tapeworm Echinococcus multilocularis causes the lethal disease alve...
Trypanosoma brucei are unicellular parasites endemic to Sub-Saharan Africa that cause fatal disease ...
BackgroundSchistosomiasis is highly prevalent in Africa. Praziquantel is effective against adult sch...
<div><p>Novel drugs to treat human African trypanosomiasis (HAT) are still urgently needed despite t...
BackgroundChemotherapy is a principle tool for the control and prevention of piroplasmosis. The sear...
The problems of parasite resistance, as well as the toxic residues to most of the commercially avail...
BackgroundChemotherapy is a principle tool for the control and prevention of piroplasmosis. The sear...
Babesiosis is an emerging tick-borne disease caused by apicomplexan parasites of the genus Babesia. ...
Background:Treatment is the principle way to control and eliminate piroplasmosis. The search for new...
Babesiosis is a tick-transmitted zoonosis caused by apicomplexan parasites of the genus Babesia. Tre...
BACKGROUND: Tafenoquine (TQ) was recently approved by the US Food and Drug Administration for prophy...
Babesia bovis, Babesia bigemina and Theileria equi are worldwide tick-borne hemoprotozoan that cause...
Heat shock protein 90 (Hsp90) is a chaperone protein that stabilizes cells during stress or non-stre...
Piroplasmosis treatment has been based on the use of imidocarb dipropionate or diminazene aceturate ...
Mohamed Abdo Rizk,1,2 Mahmoud AbouLaila,3 Shimaa Abd El-Salam El-Sayed,1,4 Azirwan Guswanto,1,5 Naoa...
The metacestode stage of the fox tapeworm Echinococcus multilocularis causes the lethal disease alve...
Trypanosoma brucei are unicellular parasites endemic to Sub-Saharan Africa that cause fatal disease ...
BackgroundSchistosomiasis is highly prevalent in Africa. Praziquantel is effective against adult sch...
<div><p>Novel drugs to treat human African trypanosomiasis (HAT) are still urgently needed despite t...