Impact of blood glucose abnormalities on outcomes and disease severity in patients with severe sepsis: An analysis from a multicenter, prospective survey of severe sepsis.
- Shigeki Kushimoto
- Toshikazu Abe
- Hiroshi Ogura
- Atsushi Shiraishi
- Daizoh Saitoh
- Seitaro Fujishima
- Toshihiko Mayumi
- Toru Hifumi
- Yasukazu Shiino
- Taka-Aki Nakada
- Takehiko Tarui
- Yasuhiro Otomo
- Kohji Okamoto
- Yutaka Umemura
- Joji Kotani
- Yuichiro Sakamoto
- Junichi Sasaki
- Shin-Ichiro Shiraishi
- Kiyotsugu Takuma
- Ryosuke Tsuruta
- Akiyoshi Hagiwara
- Kazuma Yamakawa
- Tomohiko Masuno
- Naoshi Takeyama
- Norio Yamashita
- Hiroto Ikeda
- Masashi Ueyama
- Satoshi Fujimi
- Satoshi Gando
- JAAM FORECAST group
DOIAbstract
BACKGROUND:Dysglycemia is frequently observed in patients with sepsis. However, the relationship between dysglycemia and outcome is inconsistent. We evaluate the clinical characteristics, glycemic abnormalities, and the relationship between the initial glucose level and mortality in patients with sepsis. METHODS:This is a retrospective sub-analysis of a multicenter, prospective cohort study. Adult patients with severe sepsis (Sepsis-2) were divided into groups based on blood glucose categories (<70 (hypoglycemia), 70-139, 140-179, and ≥180 mg/dL), according to the admission values. In-hospital mortality and the relationship between pre-existing diabetes and septic shock were evaluated. RESULTS:Of 1158 patients, 69, 543, 233, and 313 patient...
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