Temporal and spatial modulation of the tumor and systemic immune response in the murine Gl261 glioma model.

Kelly J McKelvey
Amanda L Hudson
Ramyashree Prasanna Kumar
James S Wilmott
Grace H Attrill
Georgina V Long
Richard A Scolyer
Stephen J Clarke
Helen R Wheeler
Connie I Diakos
Viive M Howell

Open link

Publication date

January 2020

DOI

10.1371/journal.pone.0226444

Publisher

Public Library of Science (PLoS)

Journal

PLoS ONE

Abstract

Glioblastoma, the most aggressive form of glioma, has a 5-year survival rate of 30% Ki67 and increased tissue vascularization (p<0.05). Increasing tumor proliferation/malignancy and vascularization were associated with significant temporal changes in immune cell populations within the tumor (p<0.05) and systemic compartments (p = 0.02 to p<0.0001). Of note, at day 14 16/24 plasma cytokine/chemokines levels decreased coinciding with an increase in tumor cytotoxic T cells, natural killer and natural killer/T cells. Data derived provide baseline characterization of the local and systemic immune response during glioma development. They reveal that type II macrophages and myeloid-derived suppressor cells are more prevalent in tumors than regulat...