Mitochondria are quantitatively the most important sources of reactive oxygen species (ROS) which are formed as by-products during cellular respiration. ROS generation occurs when single electrons are transferred to molecular oxygen. This leads to a number of different ROS types, among them superoxide. Although most studies focus on ROS generation in the mitochondrial matrix, the intermembrane space (IMS) is also important in this regard. The main scavengers for the detoxification of superoxide in the IMS are Cu, Zn superoxide dismutase (SOD1) and cytochrome-c. Similar to ROS, certain reactive carbonyl species are known for their high reactivity. The consequences are deleterious modifications to essential components compromising cellular fu...
Thiol-disulfide balance is critical for the proper functioning of many proteins. Reduced thiol resid...
Superoxide dismutases (SODs) represent the first line of defense against oxidative stress, which is ...
Reactive oxygen species (ROS) are cytotoxic. To remove ROS, cells have developed ROS-specific defens...
Methylglyoxal (MG) is a highly reactive aldehyde spontaneously formed in human cells mainly as a by-...
The glycation of protein and nucleic acids that occurs as a consequence of hyperglycaemia disrupts c...
Reactive oxygen species (ROS) are produced constantly inside the cells as a consequence of nutrient ...
Superoxide is the primary reactive oxygen species generated in the mitochondria. Manganese superoxid...
AbstractThe glycation of protein and nucleic acids that occurs as a consequence of hyperglycemia dis...
Superoxide dismutases (SODs) are necessary antioxidant enzymes that protect cells from reactive oxyg...
Superoxide is the primary reactive oxygen species generated in the mitochondria. Manganese superoxid...
Advanced glycation end products (AGEs) are found in various intraneuronal protein deposits such as n...
Methylglyoxal (MGO) is a highly reactive cellular metabolite that glycates lysine and arginine resid...
Increasing evidence indicates that the accumulation and aggregation of mutant Cu,Zn superoxide dismu...
Methylglyoxal (MG) is a potent protein glycating agent. Glycation is directed to guanidino groups of...
The formation and accumulation of methylglyoxal (MGO), a highly reactive dicarbonyl compound, has be...
Thiol-disulfide balance is critical for the proper functioning of many proteins. Reduced thiol resid...
Superoxide dismutases (SODs) represent the first line of defense against oxidative stress, which is ...
Reactive oxygen species (ROS) are cytotoxic. To remove ROS, cells have developed ROS-specific defens...
Methylglyoxal (MG) is a highly reactive aldehyde spontaneously formed in human cells mainly as a by-...
The glycation of protein and nucleic acids that occurs as a consequence of hyperglycaemia disrupts c...
Reactive oxygen species (ROS) are produced constantly inside the cells as a consequence of nutrient ...
Superoxide is the primary reactive oxygen species generated in the mitochondria. Manganese superoxid...
AbstractThe glycation of protein and nucleic acids that occurs as a consequence of hyperglycemia dis...
Superoxide dismutases (SODs) are necessary antioxidant enzymes that protect cells from reactive oxyg...
Superoxide is the primary reactive oxygen species generated in the mitochondria. Manganese superoxid...
Advanced glycation end products (AGEs) are found in various intraneuronal protein deposits such as n...
Methylglyoxal (MGO) is a highly reactive cellular metabolite that glycates lysine and arginine resid...
Increasing evidence indicates that the accumulation and aggregation of mutant Cu,Zn superoxide dismu...
Methylglyoxal (MG) is a potent protein glycating agent. Glycation is directed to guanidino groups of...
The formation and accumulation of methylglyoxal (MGO), a highly reactive dicarbonyl compound, has be...
Thiol-disulfide balance is critical for the proper functioning of many proteins. Reduced thiol resid...
Superoxide dismutases (SODs) represent the first line of defense against oxidative stress, which is ...
Reactive oxygen species (ROS) are cytotoxic. To remove ROS, cells have developed ROS-specific defens...