Limb-girdle muscular dystrophy type 2B (LGMD2B) is caused by mutations in the dysferlin gene, resulting in non-functional dysferlin, a key protein found in muscle membrane. Treatment options available for patients are chiefly palliative in nature and focus on maintaining ambulation. Our hypothesis is that galectin-1 (Gal-1), a soluble carbohydrate binding protein, increases membrane repair capacity and myogenic potential of dysferlin-deficient muscle cells and muscle fibers. To test this hypothesis, we used recombinant human galectin-1 (rHsGal-1) to treat dysferlin-deficient models. We show that rHsGal-1 treatments of 48 h-72 h promotes myogenic maturation as indicated through improvements in size, myotube alignment, myoblast migration, and...
Dysferlin is a transmembrane protein implicated in surface membrane repair of muscle cells. Mutation...
International audienceDysferlinopathies are autosomal recessive, progressive muscle dystrophies caus...
Background The plasma membranes of striated muscle cells are particularly susceptible to rupture as ...
Two of the main pathologies characterizing dysferlinopathies are disrupted muscle membrane repair an...
Duchenne muscular dystrophy (DMD) is a fatal neuromuscular disease caused by mutations in the dystro...
Muscle degenerative diseases such as Duchenne Muscular Dystrophy are incurable and treatment options...
<div><p>Mutations in the dysferlin gene cause the most frequent adult-onset limb girdle muscular dys...
Mutations in the dysferlin gene cause the most frequent adult-onset limb girdle muscular dystrophy, ...
Mutations in the dysferlin gene are the cause of Limb-girdle Muscular Dystrophy type 2B and Miyoshi ...
Mutations in the dysferlin gene are the cause of Limb-girdle Muscular Dystrophy type 2B and Miyoshi ...
Muscular dystrophy covers a group of genetically deter-mined disorders that cause progressive weakne...
Efficient sarcolemmal repair is required for muscle cell survival, with deficits in this process lea...
International audienceDysferlin deficiency compromises the repair of injured muscle, but the underly...
Skeletal muscle undergoes many micro-membrane lesions at physiological state. Based on their sizes a...
International audienceSkeletal muscle undergoes many micro-membrane lesions at physiological state. ...
Dysferlin is a transmembrane protein implicated in surface membrane repair of muscle cells. Mutation...
International audienceDysferlinopathies are autosomal recessive, progressive muscle dystrophies caus...
Background The plasma membranes of striated muscle cells are particularly susceptible to rupture as ...
Two of the main pathologies characterizing dysferlinopathies are disrupted muscle membrane repair an...
Duchenne muscular dystrophy (DMD) is a fatal neuromuscular disease caused by mutations in the dystro...
Muscle degenerative diseases such as Duchenne Muscular Dystrophy are incurable and treatment options...
<div><p>Mutations in the dysferlin gene cause the most frequent adult-onset limb girdle muscular dys...
Mutations in the dysferlin gene cause the most frequent adult-onset limb girdle muscular dystrophy, ...
Mutations in the dysferlin gene are the cause of Limb-girdle Muscular Dystrophy type 2B and Miyoshi ...
Mutations in the dysferlin gene are the cause of Limb-girdle Muscular Dystrophy type 2B and Miyoshi ...
Muscular dystrophy covers a group of genetically deter-mined disorders that cause progressive weakne...
Efficient sarcolemmal repair is required for muscle cell survival, with deficits in this process lea...
International audienceDysferlin deficiency compromises the repair of injured muscle, but the underly...
Skeletal muscle undergoes many micro-membrane lesions at physiological state. Based on their sizes a...
International audienceSkeletal muscle undergoes many micro-membrane lesions at physiological state. ...
Dysferlin is a transmembrane protein implicated in surface membrane repair of muscle cells. Mutation...
International audienceDysferlinopathies are autosomal recessive, progressive muscle dystrophies caus...
Background The plasma membranes of striated muscle cells are particularly susceptible to rupture as ...