The adhesion G-protein coupled receptor Adgrg6 (formerly Gpr126) is instrumental in the development, maintenance and repair of peripheral nervous system myelin. The prion protein (PrP) is a potent activator of Adgrg6 and could be used as a potential therapeutic agent in treating peripheral demyelinating and dysmyelinating diseases. We designed a dimeric Fc-fusion protein comprising the myelinotrophic domain of PrP (FT2Fc), which activated Adgrg6 in vitro and exhibited favorable pharmacokinetic properties for in vivo treatment of peripheral neuropathies. While chronic FT2Fc treatment elicited specific transcriptomic changes in the sciatic nerves of PrP knockout mice, no amelioration of the early molecular signs demyelination was detected. In...
Cellular prion protein (PrPC) is a widely expressed glycosylphosphatidylinositol-anchored membrane p...
We reported that expression of the cellular prion protein (PrPC) rescues doppel (Dpl)-induced cerebe...
International audienceThe cellular prion protein (PrPC), a cell surface glycoprotein originally iden...
The adhesion G-protein coupled receptor Adgrg6 (formerly Gpr126) is instrumental in the development,...
Treatment options for many peripheral nerve diseases are limited, and the regeneration in disease or...
The cellular prion protein (PrP) is essential to the long-term maintenance of myelin sheaths in peri...
The cellular prion protein (PrP) is essential to the long-term maintenance of myelin sheaths in peri...
Ablation of the cellular prion protein PrPC leads to a chronic demyelinating polyneuropathy affectin...
The integrity of peripheral nerves relies on communication between axons and Schwann cells. The axon...
PrP(C)-deficient mice expressing prion protein variants with large amino-proximal deletions (termed ...
The cellular form of the prion protein (PrPC) has been widely investigated since its alternative fol...
Cellular prion protein (PrPC) is a glycosylphosphatidylinositol (GPI)-anchored protein most abundant...
The cellular prion protein PrP(C) confers susceptibility to transmissible spongiform encephalopathie...
Myelin is a multilayered insulating membrane that allows rapid propagation of electrical signals and...
The prion consists essentially of PrP(Sc), a misfolded and aggregated conformer of the cellular prot...
Cellular prion protein (PrPC) is a widely expressed glycosylphosphatidylinositol-anchored membrane p...
We reported that expression of the cellular prion protein (PrPC) rescues doppel (Dpl)-induced cerebe...
International audienceThe cellular prion protein (PrPC), a cell surface glycoprotein originally iden...
The adhesion G-protein coupled receptor Adgrg6 (formerly Gpr126) is instrumental in the development,...
Treatment options for many peripheral nerve diseases are limited, and the regeneration in disease or...
The cellular prion protein (PrP) is essential to the long-term maintenance of myelin sheaths in peri...
The cellular prion protein (PrP) is essential to the long-term maintenance of myelin sheaths in peri...
Ablation of the cellular prion protein PrPC leads to a chronic demyelinating polyneuropathy affectin...
The integrity of peripheral nerves relies on communication between axons and Schwann cells. The axon...
PrP(C)-deficient mice expressing prion protein variants with large amino-proximal deletions (termed ...
The cellular form of the prion protein (PrPC) has been widely investigated since its alternative fol...
Cellular prion protein (PrPC) is a glycosylphosphatidylinositol (GPI)-anchored protein most abundant...
The cellular prion protein PrP(C) confers susceptibility to transmissible spongiform encephalopathie...
Myelin is a multilayered insulating membrane that allows rapid propagation of electrical signals and...
The prion consists essentially of PrP(Sc), a misfolded and aggregated conformer of the cellular prot...
Cellular prion protein (PrPC) is a widely expressed glycosylphosphatidylinositol-anchored membrane p...
We reported that expression of the cellular prion protein (PrPC) rescues doppel (Dpl)-induced cerebe...
International audienceThe cellular prion protein (PrPC), a cell surface glycoprotein originally iden...