Defensins represent an evolutionary ancient family of antimicrobial peptides, which played an undeniably important role in host defense. In the present study, a defensin isoform was identified and characterized from manila clam Ruditapes philippinarum (designed as Rpdef1 alpha). Multiple alignments and phylogenetic analysis suggested that Rpdef1 alpha belonged to the defensin family. Quantitative RT-PCR and immunohistochemical analysis revealed that Rpdef1 alpha transcripts and the encoding peptide were dominantly expressed in the tissues of gills and mantle. After Vibrio anguillarum challenge, the Rpdef1 alpha transcripts were significantly up-regulated in gills of clams. In addition, rRpdef1 alpha not only showed broad-spectrum antimicrob...
Background: Big defensin is an antimicrobial peptide composed of a highly hydrophobic N-terminal reg...
Peptidoglycan recognition proteins (PGRPs) are important pattern recognition receptors in the innate...
BACKGROUND: Big defensin is an antimicrobial peptide composed of a highly hydrophobic N-terminal reg...
Defensins represent an evolutionary ancient family of antimicrobial peptides, which played an undeni...
Defensins are small cysteine-rich cationic proteins that are ubiquitously present in both vertebrate...
Antimicrobial peptides (AMPs) are important mediators of the primary host defense system against mic...
Although defensins have been isolated from a variety of metazoan, their role in cellular immunity ha...
Four types of defensins were identified in Manila clam and designated as Rpdef1, Rpdef2, Rpdef3 and ...
Antimicrobial peptides (AMPs) are important mediators of the primary defense mechanism against micro...
Bactericidal permeability-increasing protein (BPI) is an antimicrobial protein with potent endotoxin...
International audienceImmunological effectors of invasive species playing a role in addressing new c...
The immune system that plays a major role in determining host fitness in the wild, i.e. under the co...
International audienceIn invertebrates, defensins were found in arthropods and in the mussels. Here,...
Background: Big defensin is an antimicrobial peptide composed of a highly hydrophobic N-terminal reg...
Peptidoglycan recognition proteins (PGRPs) are important pattern recognition receptors in the innate...
BACKGROUND: Big defensin is an antimicrobial peptide composed of a highly hydrophobic N-terminal reg...
Defensins represent an evolutionary ancient family of antimicrobial peptides, which played an undeni...
Defensins are small cysteine-rich cationic proteins that are ubiquitously present in both vertebrate...
Antimicrobial peptides (AMPs) are important mediators of the primary host defense system against mic...
Although defensins have been isolated from a variety of metazoan, their role in cellular immunity ha...
Four types of defensins were identified in Manila clam and designated as Rpdef1, Rpdef2, Rpdef3 and ...
Antimicrobial peptides (AMPs) are important mediators of the primary defense mechanism against micro...
Bactericidal permeability-increasing protein (BPI) is an antimicrobial protein with potent endotoxin...
International audienceImmunological effectors of invasive species playing a role in addressing new c...
The immune system that plays a major role in determining host fitness in the wild, i.e. under the co...
International audienceIn invertebrates, defensins were found in arthropods and in the mussels. Here,...
Background: Big defensin is an antimicrobial peptide composed of a highly hydrophobic N-terminal reg...
Peptidoglycan recognition proteins (PGRPs) are important pattern recognition receptors in the innate...
BACKGROUND: Big defensin is an antimicrobial peptide composed of a highly hydrophobic N-terminal reg...