Background Inhibitors of apoptosis (IAPs) are critical regulators of programmed cell death that are essential for development, oncogenesis, and immune and stress responses. However, available knowledge regarding IAP is largely biased toward humans and model species, while the distribution, function, and evolutionary novelties of this gene family remain poorly understood in many taxa, including Mollusca, the second most speciose phylum of Metazoa. Results Here, we present a chromosome-level genome assembly of an economically significant bivalve, the hard clam Mercenaria mercenaria, which reveals an unexpected and dramatic expansion of the IAP gene family to 159 members, the largest IAP gene repertoire observed in any metazoan. Comparative ge...
3siThe advent of complete genomic sequencing has opened a window into genomic phenomena obscured by ...
<p>Bivalve molluscs are a highly successful and ancient Class, including over 20,000 known species, ...
C1q domain-containing (C1qDC) proteins are regarded as important players in the innate immunity of b...
Background Inhibitors of apoptosis (IAPs) are critical regulators of programmed cell death that are ...
Background: The hard clam Mercenaria mercenaria is a major marine resource along the Atlantic coasts...
Apoptosis is an essential biological process in the development and maintenance of immune system hom...
Apoptosis is an essential biological process in the development and maintenance of immune system hom...
Bivalves play vital roles in marine, brackish, freshwater and terrestrial habitats. In recent years,...
<div><p></p><p>Bivalves play vital roles in marine, brackish, freshwater and terrestrial habitats. I...
The Pacific oyster Crassostrea gigas belongs to one of the most species-rich but genomically poorly ...
The Pacific oyster Crassostrea gigas belongs to one of the most species-rich but genomically poorly ...
Background Apoptosis is an important process for an organism’s innate immune system to respond to pa...
Bivalves play vital roles in marine, brackish, freshwater and terrestrial habitats. In recent years,...
Apoptosis is an essential biological process in vertebrates and invertebrates for the development an...
Mitogen-activated protein kinase kinase (MAPKK) was the hub component of the Mitogen-activated prote...
3siThe advent of complete genomic sequencing has opened a window into genomic phenomena obscured by ...
<p>Bivalve molluscs are a highly successful and ancient Class, including over 20,000 known species, ...
C1q domain-containing (C1qDC) proteins are regarded as important players in the innate immunity of b...
Background Inhibitors of apoptosis (IAPs) are critical regulators of programmed cell death that are ...
Background: The hard clam Mercenaria mercenaria is a major marine resource along the Atlantic coasts...
Apoptosis is an essential biological process in the development and maintenance of immune system hom...
Apoptosis is an essential biological process in the development and maintenance of immune system hom...
Bivalves play vital roles in marine, brackish, freshwater and terrestrial habitats. In recent years,...
<div><p></p><p>Bivalves play vital roles in marine, brackish, freshwater and terrestrial habitats. I...
The Pacific oyster Crassostrea gigas belongs to one of the most species-rich but genomically poorly ...
The Pacific oyster Crassostrea gigas belongs to one of the most species-rich but genomically poorly ...
Background Apoptosis is an important process for an organism’s innate immune system to respond to pa...
Bivalves play vital roles in marine, brackish, freshwater and terrestrial habitats. In recent years,...
Apoptosis is an essential biological process in vertebrates and invertebrates for the development an...
Mitogen-activated protein kinase kinase (MAPKK) was the hub component of the Mitogen-activated prote...
3siThe advent of complete genomic sequencing has opened a window into genomic phenomena obscured by ...
<p>Bivalve molluscs are a highly successful and ancient Class, including over 20,000 known species, ...
C1q domain-containing (C1qDC) proteins are regarded as important players in the innate immunity of b...