Effectiveness of preeclampsia prognosis in pregnancy

With the purpose to develop and assess the effectiveness of prediction method of pre-eclampsia (PE) 177 women in III trimester of pregnancy were examined. Of them: 133 women with preeclampsia of varying severity, 44 - with uncomplicated pregnancy. Prediction method is based on testing of thrombophilia genes, level of antibodies to β2 glycoprotein-1, D-dimer, value of atherogenicity coefficient. Using maximum likelihood method risk function was designed and formula which allows to estimatie probability of pre-eclampsia development was made. For practical applications, a graphical representation of likelihood of pre-eclampsia development from the calculated risk function is given. The sensitivity of the proposed model is 82,5% (95% CI 74,2-88,9%), specificity – 90,9% (95% CI 78,3-88,9%). To evaluate the effectiveness this prediction method was tested on a group of 108 pregnant women who were tested in the first trimester. 84 pregnant women were in the group with the predicted low risk (P(y)