Hydrogen peroxide (H2O2) promotes a range of phenotypes depending on its intracellular concentration and dosing kinetics, including cell death. While this qualitative relationship has been well established, the quantitative and mechanistic aspects of H2O2 signaling are still being elucidated. Mitochondria, a putative source of intracellular H2O2, have recently been demonstrated to be particularly vulnerable to localized H2O2 perturbations, eliciting a dramatic cell death response in comparison to similar cytosolic perturbations. We sought to improve our dynamic and mechanistic understanding of the mitochondrial H2O2 reaction network in HeLa cells by creating a kinetic model of this system and using it to explore basal and perturbed conditio...
Oxidative stresses caused by reactive oxygen species (ROS) can induce rapid depolarization of inner ...
AbstractMitochondria are often regarded as a major source of reactive oxygen species (ROS) in animal...
Increased production of reactive oxygen species (ROS) in mitochondria underlies major systemic disea...
© 2020 Stein et al. This is an open access article distributed under the terms of the Creative Commo...
Mitochondria are widely recognized as sources of reactive oxygen species in animal cells, with H2O2 ...
This electronic version was submitted by the student author. The certified thesis is available in th...
For over 40 years, mitochondrial reactive oxygen species (ROS) production and balance has been studi...
Reactive Oxygen Species (ROS) generation is an unavoidable background process during normal cellular...
Among reactive oxygen species (ROS), H₂O₂ alone acts as a signaling molecule that promotes diverse p...
Reactive oxygen species are continuously formed as natural byproducts of aerobic metabolism. Despite...
<div><p>Hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) is used by phagocytic cells of the innate imm...
The chief ROS formed by mitochondria are superoxide (O2·−) and hydrogen peroxide (H2O2). Superoxide ...
Cells have elaborate responses to cues provided to them. Hydrogen peroxide (H2O2) is often produced ...
Among reactive oxygen species (ROS), H2O2 alone acts as a signaling molecule that promotes diverse p...
Oxidative stress is a feature of cardiovascular disease. Hydrogen peroxide (H2O2) can act as a signa...
Oxidative stresses caused by reactive oxygen species (ROS) can induce rapid depolarization of inner ...
AbstractMitochondria are often regarded as a major source of reactive oxygen species (ROS) in animal...
Increased production of reactive oxygen species (ROS) in mitochondria underlies major systemic disea...
© 2020 Stein et al. This is an open access article distributed under the terms of the Creative Commo...
Mitochondria are widely recognized as sources of reactive oxygen species in animal cells, with H2O2 ...
This electronic version was submitted by the student author. The certified thesis is available in th...
For over 40 years, mitochondrial reactive oxygen species (ROS) production and balance has been studi...
Reactive Oxygen Species (ROS) generation is an unavoidable background process during normal cellular...
Among reactive oxygen species (ROS), H₂O₂ alone acts as a signaling molecule that promotes diverse p...
Reactive oxygen species are continuously formed as natural byproducts of aerobic metabolism. Despite...
<div><p>Hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) is used by phagocytic cells of the innate imm...
The chief ROS formed by mitochondria are superoxide (O2·−) and hydrogen peroxide (H2O2). Superoxide ...
Cells have elaborate responses to cues provided to them. Hydrogen peroxide (H2O2) is often produced ...
Among reactive oxygen species (ROS), H2O2 alone acts as a signaling molecule that promotes diverse p...
Oxidative stress is a feature of cardiovascular disease. Hydrogen peroxide (H2O2) can act as a signa...
Oxidative stresses caused by reactive oxygen species (ROS) can induce rapid depolarization of inner ...
AbstractMitochondria are often regarded as a major source of reactive oxygen species (ROS) in animal...
Increased production of reactive oxygen species (ROS) in mitochondria underlies major systemic disea...