Free-living amoebae are thought to represent an environmental niche in which amoeba-resistant bacteria may evolve towards pathogenicity. To get more insights into factors playing a role for adaptation to intracellular life, we characterized the transcriptomic activities of the emerging pathogen Mycobacterium abscessus in amoeba and murine macrophages (Mϕ) and compared them with the intra-amoebal transcriptome of the closely related, but less pathogenic Mycobacterium chelonae. Data on up-regulated genes in amoeba point to proteins that allow M. abscessus to resist environmental stress and induce defense mechanisms, as well as showing a switch from carbohydrate carbon sources to fatty acid metabolism. For eleven of the most upregulated genes ...
The interaction of environmental bacteria with unicellular eukaryotes is generally considered a majo...
AbstractMycobacterium species evolved from an environmental recent common ancestor by reductive evol...
Mycobacterium abscessus is a fast growing mycobacterium, and an opportunistic pathogen responsible f...
International audienceFree-living amoebae are thought to represent an environmental niche in which a...
International audienceWhat differentiates Mycobacterium abscessus from other saprophytic mycobacteri...
International audienceABSTRACT Mycobacterium abscessus is a pathogenic, rapidly growing mycobacteriu...
Mycobacterium abscessus, a rapidly growing mycobacterium (RGM) and an opportunistic human pathogen, ...
Tuberculosis remains the most pervasive infectious disease and the recent emergence of multiple drug...
The interaction of environmental bacteria with unicellular eukaryotes is generally considered a majo...
The interaction of environmental bacteria with unicellular eukaryotes is generally considered a majo...
AbstractMycobacterium species evolved from an environmental recent common ancestor by reductive evol...
Mycobacterium abscessus is a fast growing mycobacterium, and an opportunistic pathogen responsible f...
International audienceFree-living amoebae are thought to represent an environmental niche in which a...
International audienceWhat differentiates Mycobacterium abscessus from other saprophytic mycobacteri...
International audienceABSTRACT Mycobacterium abscessus is a pathogenic, rapidly growing mycobacteriu...
Mycobacterium abscessus, a rapidly growing mycobacterium (RGM) and an opportunistic human pathogen, ...
Tuberculosis remains the most pervasive infectious disease and the recent emergence of multiple drug...
The interaction of environmental bacteria with unicellular eukaryotes is generally considered a majo...
The interaction of environmental bacteria with unicellular eukaryotes is generally considered a majo...
AbstractMycobacterium species evolved from an environmental recent common ancestor by reductive evol...
Mycobacterium abscessus is a fast growing mycobacterium, and an opportunistic pathogen responsible f...