Signal transducers and activators of transcription (STAT) 1 is critical for cellular responses to type I interferons (IFN-Is), with the capacity to determine the outcome of viral infection. We previously showed that while wildtype (WT) mice develop mild disease and survive infection with lymphocytic choriomeningitis virus (LCMV), LCMV infection of STAT1-deficient mice results in a lethal wasting disease that is dependent on IFN-I and CD4+ cells. IFN-Is are considered to act as a bridge between innate and adaptive immunity. Here, we determined the relative contribution of STAT1 on innate and adaptive immunity during LCMV infection. We show that STAT1 deficiency results in a biphasic disease following LCMV infection. The initial, innate immun...
<p><b>(A)</b> Change in body weight following infection with IAV. Mice were infected i.n. with IAV P...
Type I IFNs are crucial cytokines of innate immunity for combating viral infections. Signaling throu...
Signal transducer and activator of transcription 3 (STAT3) mediates cellular responses to multiple c...
Type I interferons (IFN-I) have paradoxical roles in immune responses. While being key mediators of ...
Item does not contain fulltextInterferon (IFN) signaling is crucial for antiviral immunity. While ty...
Signal transducer and activator of transcription 1 (Stat1) is a key player in responses to interfero...
<div><p>Signal transducer and activator of transcription 1 (Stat1) is a key player in responses to i...
AbstractThe STAT1 transcription factor is activated in response to many cytokines and growth factors...
Type 1 IFNs can conditionally activate all of the signal transducers and activators of transcription...
ABSTRACT Natural killer (NK) cells are equipped to innately produce the cytokine gamma interferon (I...
STAT3 is a critical transcription factor activated downstream of cytokine signaling and is integral ...
SummaryUnderstanding, treating, and preventing diseases caused by immunosuppression and/or persisten...
Type I interferons (IFN-Is) are master regulators of the immune system. They are responsible for ini...
<div><p>Signal transducer and activator of transcription (STAT) 1 is a key player in interferon (IFN...
Signal transducer and activator of transcription (STAT) 1 is a key player in interferon (IFN) signal...
<p><b>(A)</b> Change in body weight following infection with IAV. Mice were infected i.n. with IAV P...
Type I IFNs are crucial cytokines of innate immunity for combating viral infections. Signaling throu...
Signal transducer and activator of transcription 3 (STAT3) mediates cellular responses to multiple c...
Type I interferons (IFN-I) have paradoxical roles in immune responses. While being key mediators of ...
Item does not contain fulltextInterferon (IFN) signaling is crucial for antiviral immunity. While ty...
Signal transducer and activator of transcription 1 (Stat1) is a key player in responses to interfero...
<div><p>Signal transducer and activator of transcription 1 (Stat1) is a key player in responses to i...
AbstractThe STAT1 transcription factor is activated in response to many cytokines and growth factors...
Type 1 IFNs can conditionally activate all of the signal transducers and activators of transcription...
ABSTRACT Natural killer (NK) cells are equipped to innately produce the cytokine gamma interferon (I...
STAT3 is a critical transcription factor activated downstream of cytokine signaling and is integral ...
SummaryUnderstanding, treating, and preventing diseases caused by immunosuppression and/or persisten...
Type I interferons (IFN-Is) are master regulators of the immune system. They are responsible for ini...
<div><p>Signal transducer and activator of transcription (STAT) 1 is a key player in interferon (IFN...
Signal transducer and activator of transcription (STAT) 1 is a key player in interferon (IFN) signal...
<p><b>(A)</b> Change in body weight following infection with IAV. Mice were infected i.n. with IAV P...
Type I IFNs are crucial cytokines of innate immunity for combating viral infections. Signaling throu...
Signal transducer and activator of transcription 3 (STAT3) mediates cellular responses to multiple c...