The pathogenesis of osteoporosis is considered extremely intricate. Osteoblast differentiation and angiogenesis can greatly affect bone development and formation, given their coupling role in these processes. Exosome-mediated miRNA regulates cellular senescence, proliferation, and differentiation. However, whether senescent osteoblasts can regulate the senescence of vascular endothelial cell by miRNA through exosomal pathway remains unclear. In this study, senescent osteoblasts could regulate endothelial cell function, promote cell senescence and apoptosis, and decrease cell proliferation via exosomal pathway. miR-139-5p showed high expression in senescent osteoblasts and their exosomes. After senescent osteoblast-derived exosome treatment,...
BACKGROUND: Increasing evidence has demonstrated that the senescence of vascular endothelial cells h...
The physiological role of microRNAs (miRNAs) in osteoblast differentiation remains elusive. Exosomal...
The most common primary malignant bone sarcoma is Osteogenic sarcoma (OS) which has a bimodal age di...
MicroRNAs (miRNAs) regulate various cellular processes. While several genes associated with replicat...
Abstract As societal aging intensifies, senile osteoporosis has become a global public health concer...
Abstract Senescent endothelial cells (ECs) could impair the integrity of the blood vessel endotheliu...
Extracellular vesicles are mediators of intercellular communication with critical roles in cellular ...
Mechanical unloading-related bone loss adversely harms astronauts’ health. Nevertheless, the specifi...
Damage to cells and tissues is one of the driving forces of aging and age-related diseases. Various ...
Cellular senescence is a complex, dynamic process consisting of the irreversible arrest of growth an...
Age-related bone diseases are partly caused by impaired bone integrity, which are closely related to...
Senescent osteoblast overburden accelerates bone mass loss. Little is understood about microRNA cont...
Accumulation of senescent endothelial cells can cause endothelium dysfunction which eventually leads...
AbstractMultiple mechanisms of senescence induction exist including telomere attrition, oxidative st...
Endothelial cells (ECs) form monolayers and line the interior surfaces of blood vessels in the entir...
BACKGROUND: Increasing evidence has demonstrated that the senescence of vascular endothelial cells h...
The physiological role of microRNAs (miRNAs) in osteoblast differentiation remains elusive. Exosomal...
The most common primary malignant bone sarcoma is Osteogenic sarcoma (OS) which has a bimodal age di...
MicroRNAs (miRNAs) regulate various cellular processes. While several genes associated with replicat...
Abstract As societal aging intensifies, senile osteoporosis has become a global public health concer...
Abstract Senescent endothelial cells (ECs) could impair the integrity of the blood vessel endotheliu...
Extracellular vesicles are mediators of intercellular communication with critical roles in cellular ...
Mechanical unloading-related bone loss adversely harms astronauts’ health. Nevertheless, the specifi...
Damage to cells and tissues is one of the driving forces of aging and age-related diseases. Various ...
Cellular senescence is a complex, dynamic process consisting of the irreversible arrest of growth an...
Age-related bone diseases are partly caused by impaired bone integrity, which are closely related to...
Senescent osteoblast overburden accelerates bone mass loss. Little is understood about microRNA cont...
Accumulation of senescent endothelial cells can cause endothelium dysfunction which eventually leads...
AbstractMultiple mechanisms of senescence induction exist including telomere attrition, oxidative st...
Endothelial cells (ECs) form monolayers and line the interior surfaces of blood vessels in the entir...
BACKGROUND: Increasing evidence has demonstrated that the senescence of vascular endothelial cells h...
The physiological role of microRNAs (miRNAs) in osteoblast differentiation remains elusive. Exosomal...
The most common primary malignant bone sarcoma is Osteogenic sarcoma (OS) which has a bimodal age di...