Macrophages have a defined role in the pathogenesis of metabolic disease and cholesterol metabolism where alternative activation of macrophages is thought to be beneficial to both glucose and cholesterol metabolism during high fat diet induced disease. It is well established that helminth infection protects from metabolic disease, but the mechanisms underlying protection are not well understood. Here, we investigated the effects of Schistosoma mansoni infection and cytokine activation in the metabolic signatures of bone marrow derived macrophages using an approach that integrated transcriptomics, metabolomics, and lipidomics in a metabolic disease prone mouse model. We demonstrate that bone marrow derived macrophages (BMDM) from S. mansoni ...
Summary: In concert with their phagocytic activity, macrophages are thought to regulate the host imm...
chronic infection on the pathogenesis of this metabolic disorder are not completely understood.We e...
Toxoplasma gondii is capable of actively invading almost any mammalian cell type including phagocyte...
Hepatic macrophages play an essential role in the granulomatous response to infection with the para...
Hepatic macrophages play an essential role in the granulomatous response to infection with the paras...
International audienceWe analyzed the transcriptional signatures of mouse bone marrow-derived macrop...
We analyzed the transcriptional signatures of mouse bone marrow-derived macrophages at different tim...
Type 2 immunity plays an essential role in the maintenance of metabolic homeostasis and its disrupti...
<div><p>We analyzed the transcriptional signatures of mouse bone marrow-derived macrophages at diffe...
Metabolic reprogramming has emerged as a crucial regulator of immune cell activation, but how system...
Intestinal helminths are prevalent in individuals who live in rural areas of developing countries, w...
Toxoplasma gondii is one of the most successful parasites on Earth, infecting a wide array of mammal...
Cellular metabolism is intricately linked to the activation and effector function of CD4+ T cells. A...
Myeloid-derived suppressor cells (MDSCs) are a compendium of immature myeloid cells that exhibit pot...
In recent years, the renewed interest in immune cell metabolism has driven the emergence of a resear...
Summary: In concert with their phagocytic activity, macrophages are thought to regulate the host imm...
chronic infection on the pathogenesis of this metabolic disorder are not completely understood.We e...
Toxoplasma gondii is capable of actively invading almost any mammalian cell type including phagocyte...
Hepatic macrophages play an essential role in the granulomatous response to infection with the para...
Hepatic macrophages play an essential role in the granulomatous response to infection with the paras...
International audienceWe analyzed the transcriptional signatures of mouse bone marrow-derived macrop...
We analyzed the transcriptional signatures of mouse bone marrow-derived macrophages at different tim...
Type 2 immunity plays an essential role in the maintenance of metabolic homeostasis and its disrupti...
<div><p>We analyzed the transcriptional signatures of mouse bone marrow-derived macrophages at diffe...
Metabolic reprogramming has emerged as a crucial regulator of immune cell activation, but how system...
Intestinal helminths are prevalent in individuals who live in rural areas of developing countries, w...
Toxoplasma gondii is one of the most successful parasites on Earth, infecting a wide array of mammal...
Cellular metabolism is intricately linked to the activation and effector function of CD4+ T cells. A...
Myeloid-derived suppressor cells (MDSCs) are a compendium of immature myeloid cells that exhibit pot...
In recent years, the renewed interest in immune cell metabolism has driven the emergence of a resear...
Summary: In concert with their phagocytic activity, macrophages are thought to regulate the host imm...
chronic infection on the pathogenesis of this metabolic disorder are not completely understood.We e...
Toxoplasma gondii is capable of actively invading almost any mammalian cell type including phagocyte...