Rab27a co-ordinates actin-dependent transport by controlling organelle-associated motors and track assembly proteins
- Noura Alzahofi
- Tobias Welz
- Christopher L. Robinson
- Emma L. Page
- Deborah A. Briggs
- Amy K. Stainthorp
- James Reekes
- David A. Elbe
- Felix Straub
- Wouter W. Kallemeijn
- Edward W. Tate
- Philip S. Goff
- Elena V. Sviderskaya
- Marta Cantero
- Lluis Montoliu
- Francois Nedelec
- Amanda K. Miles
- Maryse Bailly
- Eugen Kerkhoff
- Alistair N. Hume
Publication date
July 2020
DOI Publisher
Springer Science and Business Media LLC Journal
Nature CommunicationsAbstract
Melanosomes traffic along F-actin in melanocytes. Here, the authors show that Rab27a coordinates SPIRE/FMN actin assembly and MyoVa motor proteins to generate a cell-wide actin/myosin network that links melanosomes and allows the collective activity of these force generators to drive their traffic
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