An amphipathic peptide with antibiotic activity against multidrug-resistant Gram-negative bacteria
- Alysha G. Elliott
- Johnny X. Huang
- Søren Neve
- Johannes Zuegg
- Ingrid A. Edwards
- Amy K. Cain
- Christine J. Boinett
- Lars Barquist
- Carina Vingsbo Lundberg
- Jason Steen
- Mark S. Butler
- Mehdi Mobli
- Kaela M. Porter
- Mark A. T. Blaskovich
- Sergio Lociuro
- Magnus Strandh
- Matthew A. Cooper
Publication date
June 2020
DOI Publisher
Springer Science and Business Media LLC Journal
Nature CommunicationsAbstract
Peptide antibiotics often display a very narrow therapeutic index. Here, the authors present an optimized peptide antibiotic with broad-spectrum in vitro activities, in vivo efficacy in multiple disease models against multidrug-resistant Gram-negative infections, and reduced toxicity
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