Spinal cord injury causes chronic bone marrow failure
- Randall S. Carpenter
- Jessica M. Marbourg
- Faith H. Brennan
- Katherine A. Mifflin
- Jodie C. E. Hall
- Roselyn R. Jiang
- Xiaokui M. Mo
- Malith Karunasiri
- Matthew H. Burke
- Adrienne M. Dorrance
- Phillip G. Popovich
Publication date
July 2020
DOI Publisher
Springer Science and Business Media LLC Journal
Nature CommunicationsAbstract
Spinal cord injury (SCI) often leads to immune dysfunction, but mechanistic insights are still lacking. Here the authors show that SCI alters chemokine signaling and induces long, persisting defects in hematopoietic stem and progenitor cell migration, thereby entrapping them in the bone marrow and disrupting peripheral immune homeostasis
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