Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms
- Linfeng Gao
- Max Emperle
- Yiran Guo
- Sara A. Grimm
- Wendan Ren
- Sabrina Adam
- Hidetaka Uryu
- Zhi-Min Zhang
- Dongliang Chen
- Jiekai Yin
- Michael Dukatz
- Hiwot Anteneh
- Renata Z. Jurkowska
- Jiuwei Lu
- Yinsheng Wang
- Pavel Bashtrykov
- Paul A. Wade
- Gang Greg Wang
- Albert Jeltsch
- Jikui Song
Publication date
July 2020
DOI Publisher
Springer Science and Business Media LLC Journal
Nature CommunicationsAbstract
In mammals, DNA methylation patterns are established by two de novo DNA methyltransferases, DNMT3A and DNMT3B. Here the authors report the crystal structures of DNMT3B in complex with both CpG and CpA DNA, providing insight into the substrate-recognition mechanism underpinning the divergent genomic methylation activities of DNMT3A and DNMT3B
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