The Bartonella autotransporter BafA activates the host VEGF pathway to drive angiogenesis
- Kentaro Tsukamoto
- Naoaki Shinzawa
- Akito Kawai
- Masahiro Suzuki
- Hiroyasu Kidoya
- Nobuyuki Takakura
- Hisateru Yamaguchi
- Toshiki Kameyama
- Hidehito Inagaki
- Hiroki Kurahashi
- Yasuhiko Horiguchi
- Yohei Doi
Publication date
July 2020
DOI Publisher
Springer Science and Business Media LLC Journal
Nature CommunicationsAbstract
Pathogenic bacteria of the genus Bartonella can induce vasoproliferative lesions during infection. Here, Tsukamoto et al. show that this effect is caused by a secreted protein that induces cell proliferation and angiogenesis by acting as an analog of the host’s vascular endothelial growth factor (VEGF)
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