Pre-clinical study of induced pluripotent stem cell-derived dopaminergic progenitor cells for Parkinson’s disease
- Daisuke Doi
- Hiroaki Magotani
- Tetsuhiro Kikuchi
- Megumi Ikeda
- Satoe Hiramatsu
- Kenji Yoshida
- Naoki Amano
- Masaki Nomura
- Masafumi Umekage
- Asuka Morizane
- Jun Takahashi
Publication date
July 2020
DOI Publisher
Springer Science and Business Media LLC Journal
Nature CommunicationsAbstract
Induced pluripotent stem cell (iPSC) derived dopaminergic neurons are a promising source for cell-based Parkinson’s disease (PD) therapy. Here the authors report a comprehensive pre-clinical evaluation of the safety and efficacy of dopaminergic progenitors derived from a clinical-grade human iPSC line
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