A fluorogenic cyclic peptide for imaging and quantification of drug-induced apoptosis
- Nicole D. Barth
- Ramon Subiros-Funosas
- Lorena Mendive-Tapia
- Rodger Duffin
- Mario A. Shields
- Jennifer A. Cartwright
- Sónia Troeira Henriques
- Jesus Sot
- Felix M. Goñi
- Rodolfo Lavilla
- John A. Marwick
- Sonja Vermeren
- Adriano G. Rossi
- Mikala Egeblad
- Ian Dransfield
- Marc Vendrell
Publication date
August 2020
DOI Publisher
Springer Science and Business Media LLC Journal
Nature CommunicationsAbstract
Programmed cell death or apoptosis is an essential biological process that is impaired in some diseases and can be used to assess the effectiveness of drugs. Here the authors design Apo-15 as a fluorogenic peptide for the detection and real-time imaging of apoptotic cells
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