Direct reprogramming of human umbilical vein- and peripheral blood-derived endothelial cells into hepatic progenitor cells
- Hiroki Inada
- Miyako Udono
- Kanae Matsuda-Ito
- Kenichi Horisawa
- Yasuyuki Ohkawa
- Shizuka Miura
- Takeshi Goya
- Junpei Yamamoto
- Masao Nagasaki
- Kazuko Ueno
- Daisuke Saitou
- Mikita Suyama
- Yoshihiko Maehara
- Wataru Kumamaru
- Yoshihiro Ogawa
- Sayaka Sekiya
- Atsushi Suzuki
Publication date
October 2020
DOI Publisher
Springer Science and Business Media LLC Journal
Nature CommunicationsAbstract
The conditions to induce human hepatic progenitor cells from other cell types are unclear. Here, the authors reprogram human endothelial cells to hepatic progenitor cells by expressing FOXA3, HNF1A and HNF6, capable of giving rise to hepatocytes and cholangiocytes that reconstitute damaged liver tissues on transplantation
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