HNF4α regulates sulfur amino acid metabolism and confers sensitivity to methionine restriction in liver cancer
- Qing Xu
- Yuanyuan Li
- Xia Gao
- Kai Kang
- Jason G. Williams
- Lingfeng Tong
- Juan Liu
- Ming Ji
- Leesa J. Deterding
- Xuemei Tong
- Jason W. Locasale
- Leping Li
- Igor Shats
- Xiaoling Li
Publication date
August 2020
DOI Publisher
Springer Science and Business Media LLC Journal
Nature CommunicationsAbstract
The molecular determinants of differential responses of different cancer cells to methionine restriction are poorly understood. Here the authors show that hepatocyte nuclear factor 4α regulates sulfur amino acid metabolism and dictates the sensitivity of liver cancer to this dietary manipulation
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