Preservation of microvascular barrier function requires CD31 receptor-induced metabolic reprogramming
- Kenneth C. P. Cheung
- Silvia Fanti
- Claudio Mauro
- Guosu Wang
- Anitha S. Nair
- Hongmei Fu
- Silvia Angeletti
- Silvia Spoto
- Marta Fogolari
- Francesco Romano
- Dunja Aksentijevic
- Weiwei Liu
- Baiying Li
- Lixin Cheng
- Liwen Jiang
- Juho Vuononvirta
- Thanushiyan R. Poobalasingam
- David M. Smith
- Massimo Ciccozzi
- Egle Solito
- Federica M. Marelli-Berg
Publication date
July 2020
DOI Publisher
Springer Science and Business Media LLC Journal
Nature CommunicationsAbstract
The mechanisms that restore endothelial barrier integrity following inflammation-induced breaching are incompletely understood. Here the authors show that the CD31 immune receptor contributes to reestablishing vascular integrity via its effects on endothelial cell metabolism
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