Molecular engineering of safe and efficacious oral basal insulin
- Frantisek Hubálek
- Hanne H. F. Refsgaard
- Sanne Gram-Nielsen
- Peter Madsen
- Erica Nishimura
- Martin Münzel
- Christian Lehn Brand
- Carsten Enggaard Stidsen
- Christian Hove Claussen
- Erik Max Wulff
- Lone Pridal
- Ulla Ribel
- Jonas Kildegaard
- Trine Porsgaard
- Eva Johansson
- Dorte Bjerre Steensgaard
- Lars Hovgaard
- Tine Glendorf
- Bo Falck Hansen
- Maja Kirkegaard Jensen
- Peter Kresten Nielsen
- Svend Ludvigsen
- Susanne Rugh
- Patrick W. Garibay
- Mary Courtney Moore
- Alan D. Cherrington
- Thomas Kjeldsen
Publication date
July 2020
DOI Publisher
Springer Science and Business Media LLC Journal
Nature CommunicationsAbstract
Recently, the first orally-administered ultra-long acting insulin was shown to have clinical efficacy. Here, the authors report the molecular engineering, as well as the biological and pharmacological properties of these insulin analogues
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