Mechanism of ribosome rescue by alternative ribosome-rescue factor B
- Kai-Hsin Chan
- Valentyn Petrychenko
- Claudia Mueller
- Cristina Maracci
- Wolf Holtkamp
- Daniel N. Wilson
- Niels Fischer
- Marina V. Rodnina
Publication date
August 2020
DOI Publisher
Springer Science and Business Media LLC Journal
Nature CommunicationsAbstract
Rescue of ribosomes stalled on non-stop mRNA is essential for cell viability, and several rescue systems to resolve stalling exist in bacteria. Here, the authors use rapid kinetics and cryo-EM to reveal the pathway and selectivity mechanism of ArfB-mediated ribosome rescue
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