Mitochondrial dynamics quantitatively revealed by STED nanoscopy with an enhanced squaraine variant probe
- Xusan Yang
- Zhigang Yang
- Zhaoyang Wu
- Ying He
- Chunyan Shan
- Peiyuan Chai
- Chenshuo Ma
- Mi Tian
- Junlin Teng
- Dayong Jin
- Wei Yan
- Pintu Das
- Junle Qu
- Peng Xi
Publication date
July 2020
DOI Publisher
Springer Science and Business Media LLC Journal
Nature CommunicationsAbstract
Live cell imaging of mitochondrial cristae is challenged by the unsuitability of current fluorescent probes and high phototoxicity. Here the authors develop a squarine variant probe (MitoESq-635) that is capable of longitudinal imaging of cristae with STED with minimal phototoxicity
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