Human GBP1 binds LPS to initiate assembly of a caspase-4 activating platform on cytosolic bacteria

José Carlos Santos
Dave Boucher
Larisa Kapinos Schneider
Benjamin Demarco
Marisa Dilucca
Kateryna Shkarina
Rosalie Heilig
Kaiwen W. Chen
Roderick Y. H. Lim
Petr Broz

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Publication date

June 2020

DOI

10.1038/s41467-020-16889-z

Publisher

Springer Science and Business Media LLC

Journal

Nature Communications

Abstract

Detection of LPS derived from Gram-negative bacteria by innate immune receptors is a critical step in the host response. Here Santos and colleagues show human GBP1 binds to LPS resulting in non-canonical inflammasome activation

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Human GBP1 binds LPS to initiate assembly of a caspase-4 activating platform on cytosolic bacteria

Abstract

Extracted data

Human GBP1 binds LPS to initiate assembly of a caspase-4 activating platform on cytosolic bacteria

Abstract

Extracted data

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