There is substantial evidence that GABAB agonist, baclofen, prevents somatic and motivational responses induced by nicotine withdrawal and may target drug cue vulnerabilities in humans. In this context, we explored different aspects associated with the possible mechanisms whereby the GABAB receptors might influence nicotine withdrawal. Male mice received nicotine (2.5 mg/kg, s.c.) 4 times daily, for 7 consecutive days. Nicotine-treated mice received the nicotinic acetylcholine receptor antagonist, mecamylamine (MEC, 2 or 3.5 mg/kg, s.c.), to precipitate the withdrawal state. A second group of dependent mice received 2-hydroxysaclofen (GABAB receptor antagonist, 1 mg/kg, s.c.) before MEC-precipitated abstinence. Somatic signs of nicotine wit...
BACKGROUND: Chronic exposure to nicotine elicits physical dependence in smokers, yet the mechanism a...
The mesolimbocortical dopamine (DA) system is pivotal for the mediation of the reinforcing effects o...
Tobacco addiction is a complex form of dependence process that leads high relapse rates in people se...
The nicotine (NIC) withdrawal syndrome is considered to be a major cause of the high relapse rate am...
RATIONALE: Nicotine is a major active ingredient in tobacco and plays a major role in tobacco addict...
A previous study from our laboratory showed that baclofen (BAC, GABAB receptor agonist) was able to ...
Nicotine is the main active component of tobacco, and has both acute and chronic pharmacological eff...
Tobacco smoking continues to be a major global health hazard despite significant public awareness of...
The gamma-aminobutyric acid(GABA)-B receptor agonist baclofen is known to reduce drug intake in both...
Aims: gamma-Aminobutyric acid (GABA)-ergic transmission plays an important role in modulating reinfo...
Previous studies from our laboratory showed that baclofen (BAC, GABAB receptor agonist) prevented th...
There is an increasing demand for a novel non-nicotinic, nondopaminergic therapeutic approach to nic...
There is substantial evidence that GABAB agonist, baclofen, prevents somatic and motivational respon...
Previous studies from our laboratory showed that anxiety-related responses induced by nicotine (NIC)...
SummaryBackgroundChronic exposure to nicotine elicits physical dependence in smokers, yet the mechan...
BACKGROUND: Chronic exposure to nicotine elicits physical dependence in smokers, yet the mechanism a...
The mesolimbocortical dopamine (DA) system is pivotal for the mediation of the reinforcing effects o...
Tobacco addiction is a complex form of dependence process that leads high relapse rates in people se...
The nicotine (NIC) withdrawal syndrome is considered to be a major cause of the high relapse rate am...
RATIONALE: Nicotine is a major active ingredient in tobacco and plays a major role in tobacco addict...
A previous study from our laboratory showed that baclofen (BAC, GABAB receptor agonist) was able to ...
Nicotine is the main active component of tobacco, and has both acute and chronic pharmacological eff...
Tobacco smoking continues to be a major global health hazard despite significant public awareness of...
The gamma-aminobutyric acid(GABA)-B receptor agonist baclofen is known to reduce drug intake in both...
Aims: gamma-Aminobutyric acid (GABA)-ergic transmission plays an important role in modulating reinfo...
Previous studies from our laboratory showed that baclofen (BAC, GABAB receptor agonist) prevented th...
There is an increasing demand for a novel non-nicotinic, nondopaminergic therapeutic approach to nic...
There is substantial evidence that GABAB agonist, baclofen, prevents somatic and motivational respon...
Previous studies from our laboratory showed that anxiety-related responses induced by nicotine (NIC)...
SummaryBackgroundChronic exposure to nicotine elicits physical dependence in smokers, yet the mechan...
BACKGROUND: Chronic exposure to nicotine elicits physical dependence in smokers, yet the mechanism a...
The mesolimbocortical dopamine (DA) system is pivotal for the mediation of the reinforcing effects o...
Tobacco addiction is a complex form of dependence process that leads high relapse rates in people se...