Determination of bisphenol a migration from food packaging by dispersive liquid-liquid microextraction

In the current work, a rapid and simple dispersive liquid-liquid microextraction method (DLLME) was used to determine Bisphenol A (BPA). High performance liquid chromatography with the photodiode-array detector (HPLC-DAD) coupled DLLME method was employed to analyze BPA in food samples packaged including cans, paper boxes, and glass jars. The calibration curve was obtained to be in the linear range 0.009–25 ngg−1 with a correlation coefficient of R2 = 0.9981. The mean relative standard deviations (RSDs) was of 5.2% (n = 3). The limit of detection (LOD) and the limit of quantification (LOQ) of the method were obtained to be 0.001 ngg−1 and 0.08 ng.g−1, respectively.In sum, this method presents: • A rapid, simple and efficient modified DLLME method was used to measure BPA in packaged foods. • The advantages of this method were low detection limit, fast preparation, and high BPA recovery. • The DLLME-HPLC method consists of low detection limit and high recoveries to determine BPA in samples. • The results indicated that DLLME –HPLC-DAD was an applied method to measure BPA in food samples