4D analysis of malaria parasite invasion offers insights into erythrocyte membrane remodeling and parasitophorous vacuole formation
- Niall D. Geoghegan
- Cindy Evelyn
- Lachlan W. Whitehead
- Michal Pasternak
- Phoebe McDonald
- Tony Triglia
- Danushka S. Marapana
- Daryan Kempe
- Jennifer K. Thompson
- Michael J. Mlodzianoski
- Julie Healer
- Maté Biro
- Alan F. Cowman
- Kelly L. Rogers
Publication date
June 2021
DOI Publisher
Springer Science and Business Media LLC Journal
Nature CommunicationsAbstract
Here, Geoghegan, Evelyn et al. provide a lattice light-sheet microscopy based 4D imaging pipeline to quantitatively investigate Plasmodium spp. invasion and show that the nascent parasitophorous vacuole is predominantly formed from host’s erythrocyte membrane and undergoes continuous remodeling throughout invasion
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