BRN2 is a non-canonical melanoma tumor-suppressor
- Michael Hamm
- Pierre Sohier
- Valérie Petit
- Jérémy H. Raymond
- Véronique Delmas
- Madeleine Le Coz
- Franck Gesbert
- Colin Kenny
- Zackie Aktary
- Marie Pouteaux
- Florian Rambow
- Alain Sarasin
- Nisamanee Charoenchon
- Alfonso Bellacosa
- Luis Sanchez-del-Campo
- Laura Mosteo
- Martin Lauss
- Dies Meijer
- Eirikur Steingrimsson
- Göran B. Jönsson
- Robert A. Cornell
- Irwin Davidson
- Colin R. Goding
- Lionel Larue
Publication date
June 2021
DOI Publisher
Springer Science and Business Media LLC Journal
Nature CommunicationsAbstract
The transcription factor BRN2 regulates melanoma migration and invasion, but its role during melanoma initiation is unclear. Here the authors show that BRN2 is a haplo-insufficient tumour suppressor that positively regulates PTEN expression and in the context of BRAF mutation and heterozygous PTEN, BRN2 loss promotes melanoma initiation and progression
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