Vpr counteracts the restriction of LAPTM5 to promote HIV-1 infection in macrophages

Li Zhao
Shumei Wang
Meng Xu
Yang He
Xiaowei Zhang
Ying Xiong
Hong Sun
Haibo Ding
Wenqing Geng
Hong Shang
Guoxin Liang

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Publication date

June 2021

DOI

10.1038/s41467-021-24087-8

Publisher

Springer Science and Business Media LLC

Journal

Nature Communications

Abstract

Here, using proteomics and cell-based assays, the authors show that HIV accessory protein Vpr mediates the degradation of host lysosomal-associated transmembrane protein 5 (LAPTM5) in monocyte-derived macrophages (MDM) to enhance infection in macrophages

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Vpr counteracts the restriction of LAPTM5 to promote HIV-1 infection in macrophages

Abstract

Extracted data

Vpr counteracts the restriction of LAPTM5 to promote HIV-1 infection in macrophages

Abstract

Extracted data

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