Hematopoietic stem and progenitor cell-restricted Cdx2 expression induces transformation to myelodysplasia and acute leukemia
- Therese Vu
- Jasmin Straube
- Amy H. Porter
- Megan Bywater
- Axia Song
- Victoria Ling
- Leanne Cooper
- Gabor Pali
- Claudia Bruedigam
- Sebastien Jacquelin
- Joanne Green
- Graham Magor
- Andrew Perkins
- Alistair M. Chalk
- Carl R. Walkley
- Florian H. Heidel
- Pamela Mukhopadhyay
- Nicole Cloonan
- Stefan Gröschel
- Jan-Philipp Mallm
- Stefan Fröhling
- Claudia Scholl
- Steven W. Lane
Publication date
June 2020
DOI Publisher
Springer Science and Business Media LLC Journal
Nature CommunicationsAbstract
The caudal-related homeobox transcription factor CDX2 is expressed in leukemic cells in the majority of patients with leukemia but not during normal blood formation. Here, the authors report a mouse model with conditional Cdx2 expression showing de novo leukemic transformation, and use it to optimize treatment in high-risk AML
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