MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis
- Andre L. Samson
- Ying Zhang
- Niall D. Geoghegan
- Xavier J. Gavin
- Katherine A. Davies
- Michael J. Mlodzianoski
- Lachlan W. Whitehead
- Daniel Frank
- Sarah E. Garnish
- Cheree Fitzgibbon
- Anne Hempel
- Samuel N. Young
- Annette V. Jacobsen
- Wayne Cawthorne
- Emma J. Petrie
- Maree C. Faux
- Kristy Shield-Artin
- Najoua Lalaoui
- Joanne M. Hildebrand
- John Silke
- Kelly L. Rogers
- Guillaume Lessene
- Edwin D. Hawkins
- James M. Murphy
Publication date
June 2020
DOI Publisher
Springer Science and Business Media LLC Journal
Nature CommunicationsAbstract
Mixed lineage kinase domain-like (MLKL) is the terminal protein in the pro-inflammatory necroptotic cell death program. Here the authors show that MLKL trafficking and plasma membrane accumulation are crucial necroptosis checkpoints, and that accumulation of phosphorylated MLKL at intercellular junctions promotes necroptosis
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