Topoisomerase 3β knockout mice show transcriptional and behavioural impairments associated with neurogenesis and synaptic plasticity
- Yuyoung Joo
- Yutong Xue
- Yue Wang
- Ross A. McDevitt
- Nirnath Sah
- Simone Bossi
- Shuaikun Su
- Seung Kyu Lee
- Wei Peng
- Aoji Xie
- Yongqing Zhang
- Yi Ding
- Wai Lim Ku
- Soumita Ghosh
- Kenneth Fishbein
- Weiping Shen
- Richard Spencer
- Kevin Becker
- Keji Zhao
- Mark P. Mattson
- Henriette van Praag
- Alexei Sharov
- Weidong Wang
Publication date
June 2020
DOI Publisher
Springer Science and Business Media LLC Journal
Nature CommunicationsAbstract
Topoisomerase 3β (Top3β) solves topological stress in DNA or RNA metabolism and its mutations are linked to mental disorders. Here, the authors describe transcriptional and behavioural impairments in Top3β-knockout mice and show that these are linked to impaired neurogenesis and synaptic plasticity
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