Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Biology, 2001.Includes bibliographical references.The majority proteins that misfold in the endoplasmic reticulum (ER) are dislocated to the cytoplasm for degradation by the proteasome. This process of dislocation and degradation occurs in several steps. First, unfolded proteins need to be recognized in the ER. Following recognition, unfolded proteins are transported from the ER to the cytoplasm. Once in the cytoplasm, the misfolded proteins are processed and destroyed by the proteasome. This thesis examines each step of the process from the recognition of unfolded proteins in the ER, to the processing of proteins prior to degradation. We find that the murine MHC class I molecu...
Proteins can occasionally behave aberrantly within the cell and cause a variety of physiological iss...
In the endoplasmic reticulum (ER), nascent membrane and secreted proteins that are misfolded are ret...
The folding and assembly of proteins in the endoplasmic reticulum (ER) lumen and membrane are monito...
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2003.Includes bibliographi...
Protein misfolding is a common cellular event that can produce intrinsically harmful prod-ucts. To r...
Proteins destined for the secretory pathway are translocated into the endoplasmic reticulum (ER), wh...
Misfolded proteins are generally recognised by cellular quality control machinery, which typically r...
In eukaryotes, nascent proteins that are destined for the secretory pathway enter the endoplasmic re...
Protein quality control is an essential function of the endoplasmic reticulum. Misfolded proteins un...
BACKGROUND: Misfolded proteins are generally recognised by cellular quality control machinery, which...
The endoplasmic reticulum (ER) is the site of synthesis for nearly one-third of the eukaryotic prote...
AbstractProtein quality control and subsequent elimination of terminally misfolded proteins occurs v...
The endoplasmic reticulum (ER) is the site of synthesis for nearly one-third of the eukaryotic prote...
Selective degradation of proteins at the endoplasmic reticulum (ER-associated degradation) is though...
A quality control system in the endoplasmic reticulum (ER) efficiently discriminates polypeptides th...
Proteins can occasionally behave aberrantly within the cell and cause a variety of physiological iss...
In the endoplasmic reticulum (ER), nascent membrane and secreted proteins that are misfolded are ret...
The folding and assembly of proteins in the endoplasmic reticulum (ER) lumen and membrane are monito...
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2003.Includes bibliographi...
Protein misfolding is a common cellular event that can produce intrinsically harmful prod-ucts. To r...
Proteins destined for the secretory pathway are translocated into the endoplasmic reticulum (ER), wh...
Misfolded proteins are generally recognised by cellular quality control machinery, which typically r...
In eukaryotes, nascent proteins that are destined for the secretory pathway enter the endoplasmic re...
Protein quality control is an essential function of the endoplasmic reticulum. Misfolded proteins un...
BACKGROUND: Misfolded proteins are generally recognised by cellular quality control machinery, which...
The endoplasmic reticulum (ER) is the site of synthesis for nearly one-third of the eukaryotic prote...
AbstractProtein quality control and subsequent elimination of terminally misfolded proteins occurs v...
The endoplasmic reticulum (ER) is the site of synthesis for nearly one-third of the eukaryotic prote...
Selective degradation of proteins at the endoplasmic reticulum (ER-associated degradation) is though...
A quality control system in the endoplasmic reticulum (ER) efficiently discriminates polypeptides th...
Proteins can occasionally behave aberrantly within the cell and cause a variety of physiological iss...
In the endoplasmic reticulum (ER), nascent membrane and secreted proteins that are misfolded are ret...
The folding and assembly of proteins in the endoplasmic reticulum (ER) lumen and membrane are monito...