Synthesis and characterization of dual radiolabeled layered double hydroxide nanoparticles for use in in vitro and in vivo nanotoxicology studies.
- Musumeci, AW
- Schiller, TL
- Xu, ZP
- Minchin, RF
- Martin, DJ
- Smith, SV
DOIAbstract
Layered double hydroxide (LDH) nanomaterials are currently the focus of intense scientific interest due to their potential application in drug and gene delivery research. However, the emerging field of nanotoxicology requires the development of new and more sensitive methodologies to follow the in vivo delivery kinetics as well as the persistence and bioaccumulation of the LDH carriers subsequent to delivery of the payload to the target area. Radioisotopic labeling offers very high detection sensitivity (<10−14 moles) and straightforward quantitation with respect to other labeling techniques. We have shown that incorporation of naturally occurring Co2+ and Ga3+ cations into the LDH structure has a negligible effect on the physiochemical pro...
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