Meta-analysis of genome-wide association studies for neuroticism, and the polygenic association with Major Depressive Disorder
- Moor, M.H.M. de
- Berg, S.M. van den
- Verweij, K.J.H.
- Krueger, R.F.
- Luciano, M.
- Arias Vasquez, A.
- Matteson, L.K.
- Derringer, J.L.
- Esko, T.
- Amin, N.
- Gordon, S.D.
- Hansell, N.K.
- Hart, A.B.
- Seppälä, I.
- Huffman, J.E.
- Konte, B.
- Lahti, J.
- Lee, M.
- Miller, M.
- Nutile, T.
- Tanaka, T.
- Teumer, A.
- Viktorin, A.
- Wedenoja, J.
- Abdellaoui, A.
- Abecasis, G.R.
- Adkins, D.E.
- Agrawal, A.
- Allik, J.
- Appel, K.
- Bigdeli, T.B.
- Busonero, F.
- Campbell, H.
- Costa, P.T.
- Smith, G.D.
- Davies, G.
- Wit, H. de
- Ding, J.
- Engelhardt, B.E.
- Eriksson, J.G.
- Fedko, I.O.
- Ferrucci, L.
- Franke, B.
- Giegling, I.
- Grucza, R.A.
- Hartmann, A.M.
- Heath, A.C.
- Heinonen, K.
- Henders, A.K.
- Homuth, G.
- Hottenga, J.J.
- Iacono, W.G.
- Janzing, J.G.
- Jokela, M.
- Karlsson, R.
- Kemp, J.P.
- Kirkpatrick, M.G.
- Latvala, A.
- Lehtimäki, T.
- Liewald, D.C.
- Madden, P.A.F.
- Magri, C.
- Magnusson, P.K.E.
- Marten, J.
- Maschio, A.
- Medland, S.E.
- Mihailov, E.
- Milaneschi, Y.
- Montgomery, G.W.
- Nauck, M.
- Ouwens, K.G.
- Palotie, A.
- Pettersson, E.
- Polasek, O.
- Qian, Y.
- Pulkki-Raback, L.
- Raitakari, O.T.
- Realo, A.
- Rose, R.J.
- Ruggiero, D.
- Schmidt, C.O.
- Slutske, W.S.
- Sorice, R.
- Starr, J.M.
- St Pourcain, B.
- Sutin, A.R.
- Timpson, N.J.
- Trochet, H.
- Vermeulen, H.H.M.
- Vuoksimaa, E.
- Widen, E.
- Wouda, J.
- Wright, M.J.
- Zgaga, L.
- Porteous, D.J.
- Minelli, A.
- Palmer, A.A.
- Rujescu, D.
- Ciullo, M.
- Hayward, C.
- Rudan, I.
- Metspalu, A.
- Kaprio, J.
- Deary, I.J.
- Raikkonen, K.
- Wilson, J.F.
- Keltikangas-Jarvinen, L.
- Bierut, L.J.
- Hettema, J.M.
- Grabe, H.J.
- Penninx, B.W.J.H.
- Duijn, C.M. van
- Evans, D.M.
- Schlessinger, D.
- Pedersen, N.L.
- Terracciano, A.
- McGue, M.K.
- Martin, N.G.
- Boomsma, D.I.
DOIAbstract
Contains fulltext : 156183.pdf (publisher's version ) (Open Access)IMPORTANCE Neuroticism is a pervasive risk factor for psychiatric conditions. It genetically overlaps with major depressive disorder (MDD) and is therefore an important phenotype for psychiatric genetics. The Genetics of Personality Consortium has created a resource for genome-wide association analyses of personality traits in more than 63 000 participants (including MDD cases). OBJECTIVES To identify genetic variants associated with neuroticism by performing a meta-analysis of genome-wide association results based on 1000 Genomes imputation; to evaluate whether common genetic variants as assessed by single-nucleotide polymorphisms (SNPs) explain variation ...
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