Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease.
- Nalls, M.A.
- Pankratz, N.
- Lill, C.M.
- Do, C.B.
- Hernandez, D.G.
- Saad, M.
- DeStefano, A.L.
- Kara, E.
- Bras, J.
- Sharma, M.
- Schulte, C.
- Keller, M.F.
- Arepalli, S.
- Letson, C.
- Edsall, C.
- Stefansson, H.
- Liu, X.
- Pliner, H.
- Lee, J.H. van der
- Cheng, R.
- Ikram, M.A.
- Ioannidis, J.P.
- Hadjigeorgiou, G.M.
- Bis, J.C.
- Martinez, M.
- Perlmutter, J.S.
- Goate, A.
- Marder, K.
- Fiske, B.
- Sutherland, M.
- Xiromerisiou, G.
- Myers, R.H.
- Clark, L.N.
- Stefansson, K.
- Hardy, J.A.
- Heutink, P.
- Chen, H.
- Wood, N.W.
- Houlden, H.
- Payami, H.
- Brice, A.
- Scott, W.K.
- Gasser, T.
- Bertram, L.
- Eriksson, N.
- Foroud, T.
- Singleton, A.B.
- Scheffer, H.
- Warrenburg, B.P.C. van de
- et al.
DOIAbstract
Item does not contain fulltextWe conducted a meta-analysis of Parkinson's disease genome-wide association studies using a common set of 7,893,274 variants across 13,708 cases and 95,282 controls. Twenty-six loci were identified as having genome-wide significant association; these and 6 additional previously reported loci were then tested in an independent set of 5,353 cases and 5,551 controls. Of the 32 tested SNPs, 24 replicated, including 6 newly identified loci. Conditional analyses within loci showed that four loci, including GBA, GAK-DGKQ, SNCA and the HLA region, contain a secondary independent risk variant. In total, we identified and replicated 28 independent risk variants for Parkinson's disease across 24 loci. Although the effect ...
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