Evidence-based detection of pulmonary arterial hypertension in systemic sclerosis: the DETECT study
- Coghlan, J.G.
- Denton, C.P.
- Grunig, E.
- Bonderman, D.
- Distler, O.
- Khanna, D.
- Muller-Ladner, U.
- Pope, J.E.
- Vonk, M.C.
- Doelberg, M.
- Chadha-Boreham, H.
- Heinzl, H.
- Rosenberg, D.M.
- McLaughlin, V.V.
- Seibold, J.R.
- et al.
DOIAbstract
Contains fulltext : 137979.pdf (publisher's version ) (Open Access)OBJECTIVE: Earlier detection of pulmonary arterial hypertension (PAH), a leading cause of death in systemic sclerosis (SSc), facilitates earlier treatment. The objective of this study was to develop the first evidence-based detection algorithm for PAH in SSc. METHODS: In this cross-sectional, international study conducted in 62 experienced centres from North America, Europe and Asia, adults with SSc at increased risk of PAH (SSc for >3 years and predicted pulmonary diffusing capacity for carbon monoxide <60%) underwent a broad panel of non-invasive assessments followed by diagnostic right heart catheterisation (RHC). Univariable and multivariable analyses s...
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