Item does not contain fulltextOsteosarcoma (OS) and Ewing sarcoma (ES) are the two most common types of primary bone cancer, which mainly affect children and young adults. Despite intensive multi-modal treatment, the survival of both OS and ES has not improved much during the last decades and new therapeutic options are awaited. One promising approach is the specific targeting of transmembrane receptor tyrosine kinases (RTKs) implicated in these types of bone cancer. However, despite encouraging in vitro and in vivo results, apart from intriguing results of Insulin-like Growth Factor-1 Receptor (IGF-1R) antibodies in ES, clinical studies are limited or disappointing. Primary resistance to RTK inhibitors is frequently observed in OS and ES p...
Ewing sarcoma (ES) is thought to arise from mesenchymal stem cells and is the second most common bon...
Systemic treatment options for bone and soft tissue sarcomas remained unchanged until the 2000s. The...
Ewing sarcoma (ES) is an aggressive sarcoma of bone and soft tissue occurring at any age with a peak...
Abstract Osteosarcoma (OS) is a mesenchymal-origin tumor that constitutes the most common primary ma...
Although osteosarcoma (OS) is a rare malignancy, it is ranked among the leading causes of cancer-rel...
Ewing sarcoma is an aggressive, poorly differentiated neoplasm of solid bone that disproportionally ...
a b s t r a c t Bone cancers are characterised by the development of tumour cells in bone sites, ass...
International audiencePrimary malignant bone tumours, osteosarcomas, and Ewing sarcomas are rare dis...
The primary conclusions of our 2014 contribution to this series were as follows: Multiple receptor ...
Bone sarcomas are a collection of sporadic malignancies of mesenchymal origin. The most common subty...
Bone cancers are characterised by the development of tumour cells in bone sites, associated with a d...
AbstractBone cancers are characterised by the development of tumour cells in bone sites, associated ...
Soft tissue sarcomas (STS) are a rare, heterogeneous, and challenging group of cancers to treat effe...
Ewing sarcoma (ES) is an aggressive sarcoma of bone and soft tissue occurring at any age with a peak...
Sarcomas are a group of rare mesenchymal malignant tumors that arise from transformed cells of the m...
Ewing sarcoma (ES) is thought to arise from mesenchymal stem cells and is the second most common bon...
Systemic treatment options for bone and soft tissue sarcomas remained unchanged until the 2000s. The...
Ewing sarcoma (ES) is an aggressive sarcoma of bone and soft tissue occurring at any age with a peak...
Abstract Osteosarcoma (OS) is a mesenchymal-origin tumor that constitutes the most common primary ma...
Although osteosarcoma (OS) is a rare malignancy, it is ranked among the leading causes of cancer-rel...
Ewing sarcoma is an aggressive, poorly differentiated neoplasm of solid bone that disproportionally ...
a b s t r a c t Bone cancers are characterised by the development of tumour cells in bone sites, ass...
International audiencePrimary malignant bone tumours, osteosarcomas, and Ewing sarcomas are rare dis...
The primary conclusions of our 2014 contribution to this series were as follows: Multiple receptor ...
Bone sarcomas are a collection of sporadic malignancies of mesenchymal origin. The most common subty...
Bone cancers are characterised by the development of tumour cells in bone sites, associated with a d...
AbstractBone cancers are characterised by the development of tumour cells in bone sites, associated ...
Soft tissue sarcomas (STS) are a rare, heterogeneous, and challenging group of cancers to treat effe...
Ewing sarcoma (ES) is an aggressive sarcoma of bone and soft tissue occurring at any age with a peak...
Sarcomas are a group of rare mesenchymal malignant tumors that arise from transformed cells of the m...
Ewing sarcoma (ES) is thought to arise from mesenchymal stem cells and is the second most common bon...
Systemic treatment options for bone and soft tissue sarcomas remained unchanged until the 2000s. The...
Ewing sarcoma (ES) is an aggressive sarcoma of bone and soft tissue occurring at any age with a peak...