Adenoid cystic carcinoma can be driven by MYB or MYBL1 rearrangements: new insights into MYB and tumor biology

A majority of adenoid cystic carcinomas (AdCC)—rare tumors of the salivary gland and some other organs—have recently been found to be driven by chromosomal translocations resulting in MYB–NFIB fusions. Brayer and colleagues and Mitani and colleagues have now reported that AdCCs can alternatively be driven by similar rearrangements involving a second MYB family gene, MYBL1, and that these two drivers act in remarkably similar ways