Statins have pleiotropic effects that include attenuation of oxidative stress that may be relevant for CKD patients. We investigated the effect of long term atorvastatin therapy on oxidative stress biomarkers in CKD patients.This was a pre-specified secondary analysis of data from a randomized, double-blind, placebo-controlled trial (Lipid lowering and Onset of Renal Disease, LORD) in CKD patients. Participants received 10 mg/day atorvastatin (n=47) or placebo (n=39) for three-years. Plasma measures (total F2-isoprostanes, malondialdehyde. protein carbonyls, uric acid, glutathione peroxidase (GPx) activity and total antioxidant capacity (TAC)) were performed at baseline and at three years. Age and sex matched participants (n=34) with normal...
Lipid-lowering therapy has been reported to reduce several oxidative stress (OS) markers in hyperch...
Moderate levels of endogenous reactive oxygen species (ROS) are important for various cellular activ...
The CKD-associated decline in soluble alpha-Klotho levels is considered detrimental. Some in vitro a...
Background: Chronic kidney disease (CKD) is associated with inflammation. The effects of atorvastati...
Abstract Background Cardiovascular disease is the commonest cause of death in patients with end-stag...
Patients with chronic kidney disease (CKD) experience accelerated atherosclerosis leading to excessi...
Abstract For patients with chronic kidney disease (CKD), the leading cause of mortality is cardiovas...
BACKGROUND: Cardiovascular disease as a result of accelerated atherogenesis is common in patients wi...
Background. Neutrophil gelatinase-associated lipocalin (NGAL) and cystatin C are biomarkers of kidne...
Increased prevalence of oxidant stress and inflammation in patients with moderate to severe chronic ...
Background Kidney function decreases during the lifetime, and this decline is a powerful predictor o...
Chronic kidney disease (CKD) is a common and serious problem that adversely affects human health, li...
Background Kidney function decreases during the lifetime, and this decline is a powerful predictor o...
Background: Cardiovascular complications are the leading cause of morbidity and mortality at any sta...
The CKD-associated decline in soluble α-Klotho levels is considered detrimental. Some in vitro and i...
Lipid-lowering therapy has been reported to reduce several oxidative stress (OS) markers in hyperch...
Moderate levels of endogenous reactive oxygen species (ROS) are important for various cellular activ...
The CKD-associated decline in soluble alpha-Klotho levels is considered detrimental. Some in vitro a...
Background: Chronic kidney disease (CKD) is associated with inflammation. The effects of atorvastati...
Abstract Background Cardiovascular disease is the commonest cause of death in patients with end-stag...
Patients with chronic kidney disease (CKD) experience accelerated atherosclerosis leading to excessi...
Abstract For patients with chronic kidney disease (CKD), the leading cause of mortality is cardiovas...
BACKGROUND: Cardiovascular disease as a result of accelerated atherogenesis is common in patients wi...
Background. Neutrophil gelatinase-associated lipocalin (NGAL) and cystatin C are biomarkers of kidne...
Increased prevalence of oxidant stress and inflammation in patients with moderate to severe chronic ...
Background Kidney function decreases during the lifetime, and this decline is a powerful predictor o...
Chronic kidney disease (CKD) is a common and serious problem that adversely affects human health, li...
Background Kidney function decreases during the lifetime, and this decline is a powerful predictor o...
Background: Cardiovascular complications are the leading cause of morbidity and mortality at any sta...
The CKD-associated decline in soluble α-Klotho levels is considered detrimental. Some in vitro and i...
Lipid-lowering therapy has been reported to reduce several oxidative stress (OS) markers in hyperch...
Moderate levels of endogenous reactive oxygen species (ROS) are important for various cellular activ...
The CKD-associated decline in soluble alpha-Klotho levels is considered detrimental. Some in vitro a...