Meta-analysis of genome-wide association studies for neuroticism, and the polygenic association with major depressive disorder
- De Moor, Marleen H.M
- Van Den Berg, Stephanie M
- Verweij, Karin J.H
- Krueger, Robert F
- Luciano, Michelle
- Arias Vasquez, Alejandro
- Matteson, Lindsay K
- Derringer, Jaime
- Esko, Tonu
- Amin, Najaf
- Gordon, Scott D
- Hansell, Narelle K
- Hart, Amy B
- Seppala, Ilkka
- Huffman, Jennifer E
- Konte, Bettina
- Lahti, Jari
- Lee, Minyoung
- Miller, Mike
- Nutile, Teresa
- Tanaka, Toshiko
- Teumer, Alexander
- Viktorin, Alexander
- Wedenoja, Juho
- Abecasis, Goncalo R
- Adkins, Daniel E
- Agrawal, Arpana
- Allik, Juri
- Appel, Katja
- Bigdeli, Timothy B
- Busonero, Fabio
Publication date
July 2015
DOI Publisher
American Medical Association (AMA)Abstract
IMPORTANCE Neuroticism is a pervasive risk factor for psychiatric conditions. It genetically overlaps with major depressive disorder (MDD) and is therefore an important phenotype for psychiatric genetics. The Genetics of Personality Consortium has created a resource for genome-wide association analyses of personality traits in more than 63 000 participants (including MDD cases)
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